It has historically been assumed that tumor recurrence for non-small cell lung cancer was the result of significant molecular changes between the primary cancer and the associated metastases (distant spread).
The Study: Stephane Vignot, MD and colleagues looked at specimens from 15 patients with recurrent disease. DNA libraries were constructed for the 30 tumor samples (primary and associated metastasis)/ The goal was to compae the 2 biopsies and to identify “driver” and “passenger” mutations.
Results: There was a high concordance (agreement) of recurrent changes when comparing primary lung cancer and its associated metastasis (94%).
My take: We need bigger studies before we give up the common practice of getting a biopsy of the first site of recurrence. The application of high-throughput sequencing may lead to new targets or markers for guiding individualized therapies. I’m Dr. Michael Hunter.
J Clinical Oncology 2013 Apr 29 [epub ahead of print], PMID: 23630207
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