What You Need to Know: Scientists have explored what allows some cases of Ductal Carcinoma in Situ (DCIS), a non-invasive form of breast cancer, to resist treatment and come back, as well as identifying a potential new target to improve the effectiveness of radiotherapy.
Background: DCIS is a condition where cancerous cells are contained within the milk ducts of the breast, typically found on screening mammograms. If left untreated, up to half of DCIS cases may progress into invasive breast cancer, but it is not possible to say which ones, so all women are typically offered treatment.
Management usually involves breast-conserving surgery (lumpectomy) and, to reduce the risk of the cancer returning, radiation therapy to kill any remaining cancer cells. However, even with treatment up to one in five patients will see their DCIS come back, either as DCIS or as invasive breast cancer.
What’s New: Researchers from the Manchester (England) Cancer Research Centre — have investigated the role of a molecule known as FAK in controlling the resistance of DCIS to radiation and in predicting disease recurrence.
Dr Gillian Farnie, offers: “We know that cancer stem cells are able to avoid or repair damage caused by treatment. We wanted to look at how FAK is involved in this treatment resistance.”
The team found that cancer cell samples containing more cancer stem cells had increased levels of FAK and that these samples were better able to survive radiotherapy. By examining patient tissue samples and information about whether each person had had a recurrence, the scientists discovered that high FAK activity was linked to the disease returning, either as DCIS or invasive breast cancer.
- In further work, a drug that blocks FAK reduced the formation of mammospheres, or clumps of breast cancer stem cells, showing FAK is important in cancer stem cell activity. By combining this inhibition of FAK with radiotherapy, the group was able to achieve a greater treatment effect than with either therapy alone.
- To see if the FAK drug works in more complex living systems, the researchers gave mice with DCIS a treatment to block FAK. In treated mice the DCIS were less likely to turn into invasive-like cancer cells showing FAK is important in the progression of DCIS to invasive cancer.
“We have shown that blocking the activity of FAK not only reduces the growth of breast cancer stem cells, but also improves sensitivity to radiotherapy. Our findings suggest we can reduce the likelihood of DCIS recurring by inhibiting FAK and measuring FAK levels could offer a method to predict which patients are most likely to experience recurrence,” added Dr Farnie.
Katherine Woods, Research Communications Manager at Breast Cancer Campaign, adds: “There is still so much we don’t know about DCIS. It is vital that we get a better understanding of the biology of DCIS as well as what makes it return in some women and become invasive breast cancer.
“This knowledge could help doctors avoid over-treating those patients whose DCIS won’t come back, while making sure treatment is working for women who need it. This research is an important step in this direction, and we are excited to see how the next stages progress.
“Dr Farnie and colleagues have also provided further evidence that cancer stem cells seem be helping cancers to survive treatment. This is a fascinating new field of thought in breast cancer research, especially given the team’s findings that we might be able to stop cancer stem cells by blocking the molecule FAK.”
My Take: Interesting, but not ready for clinical use. We sorely need tools to determine those with DCIS who truly need radiation therapy, and those (the majority) who do not. I’m Dr. Michael Hunter.
The small print: The material presented herein is informational only, and is not designed to provide specific guidance for an individual. Please check with a valued health care provider with any questions or concerns. As for me, I am a Harvard- , Yale- and UPenn-educated radiation oncologist, and I practice in the Seattle, WA (USA) area. I feel genuinely privileged to be able to share with you. If you enjoyed today’s offering, please consider clicking the follow button at the bottom of this page.
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Reference: Kathryn E Williams, Nigel J Bundred, Göran Landberg, Robert B Clarke, Gillian Farnie. Focal adhesion kinase and wnt signalling regulates human ductal carcinoma in situ stem cell activity and response to radiotherapy. STEM CELLS, 2014; DOI: 10.1002/stem.1843