Breast Cancer Spread: Can Dieting Reduce Risk?

overweight obese woman

What You Need to Know: Women with an aggressive subtype of breast cancer known as “triple negative” may be able to reduce the chance of disease spreading distantly by reducing their calorie intake. But… the data thus far is based on mice (and not human) studies.

Well, it does work for mice: The study published in the Journal Breast Cancer Research and Treatment, used mice models to investigate the impact of diet on triple negative disease, which is found in about one in five women with breast cancer. It found that when mice were given 30 per cent fewer calories, changes occurred in the body in the way cells were regulated. Mice on restricted diets produced more protective proteins in the tissues around the tumour, which make it harder for cancer to spread, the study by Thomas Jefferson University found.

My Take: We know that in among some groups of women (for example, women who are post-menopausal), obesity increases the risk of breast cancer. Unfortunately, treatment such as chemotherapy (and steroids) can cause weight gain. This weight gain can lead to worse cancer outcomes. Human trials are examining the impact of calorie restriction on outcomes. For now, I advise my patients to try to achieve, and maintain, an optimal Body Mass Index (BMI) of 20 to 25. I’m Dr. Michael Hunter.

The small print: The material presented herein is informational only, and is not designed to provide specific guidance for an individual. Please check with a valued health care provider with any questions or concerns. As for me, I am a Harvard- , Yale- and UPenn-educated radiation oncologist, and I practice in the Seattle, WA (USA) area. I feel genuinely privileged to be able to share with you. If you enjoyed today’s offering, please consider clicking the follow button at the bottom of this page.

Available now: Understand Colon Cancer in 60 Minutes; Understand Brain Glioma in 60 Minutes. Both can be found at the Apple Ibooks store. Coming Soon for iPad: Understand Breast Cancer in 60 Minutes; Understand Colon Cancer in 60 Minute; Understand Colon Cancer in 60 Minutes; Understand Brain Glioma in 60 Minutes. Thank you.

Reference: http://www.telegraph.co.uk/journalists/laura-donnelly/10856597/Dieting-may-reduce-chance-of-cancer-spread.html#source=refresh:

Breast Cancer Risk: BMI Matters (Shape, Not So Much)

obese white woman

Summary: A study of predominantly white women finds a larger waist circumference is associated with higher risk of postmenopausal breast cancer, but not beyond its contribution to Body Mass Index (BMI). The study, by American Cancer Society researchers, fails to confirm previous findings that body shape itself is an independent risk factor for breast cancer. The current study appears in the April 2014 issue of Cancer Causes, and Control.

Background: Abdominal obesity is linked to a number of conditions, including heart disease, type II diabetes, and breast and other cancers. Those studies have led to the theory that having an “apple shaped” body, with weight concentrated in the chest and torso, is riskier than having a “pear-shaped” body, with fat concentrated in the hips, thighs and buttocks.

The Evidence: To explore the theory, researchers led by Mia Gadet, PhD, analyzed data from 28,965 women participating in the Cancer Prevention Study II. Among those women there were 1,088 invasive breast cancer cases diagnosed during a median 11.58 years of follow-up. They found a statistically significant positive association between waist circumference and postmenopausal breast cancer risk; however, when they adjusted for BMI, the association disappeared.

“Iif you have a high BMI, regardless if you are pear or apple shaped, you are at higher risk of breast cancer,” said Dr. Gaudet. “Most prior studies on this issue looked at BMI or at waist circumference, but had not looked at them together. This study brings some clarity to the association between obesity and risk of breast cancer.”

Dr. Gaudet says the data could help women focus on what’s important in what has been a confusing array of potential risk factors for breast cancer. “We know being overweight, particularly when the weight gain happened during adulthood, is one of the important modifiable risk factors for breast cancer in post-menopausal women. This new data indicates it’s not what shape you are, it’s what kind of shape you are in that probably ought to be their focus.” I’m Dr. Michael Hunter.

The small print: The material presented herein is informational only, and is not designed to provide specific guidance for an individual. Please check with a valued health care provider with any questions or concerns. As for me, I am a Harvard- , Yale- and UPenn-educated radiation oncologist, and I practice in the Seattle, WA (USA) area. I feel genuinely privileged to be able to share with you. If you enjoyed today’s offering, please consider clicking the follow button at the bottom of this page.

Available now: Understand Colon Cancer in 60 Minutes; Understand Brain Glioma in 60 Minutes. Both can be found at the Apple Ibooks store. Coming Soon for iPad: Understand Breast Cancer in 60 Minutes; Understand Colon Cancer in 60 Minute; Understand Colon Cancer in 60 Minutes; Understand Brain Glioma in 60 Minutes. Thank you.

Reference: Mia M. Gaudet, Brian D. Carter, Alpa V. Patel, Lauren R. Teras, Eric J. Jacobs, Susan M. Gapstur. Waist circumference, body mass index, and postmenopausal breast cancer incidence in the Cancer Prevention Study-II Nutrition Cohort. Cancer Causes & Control, 2014; DOI: 10.1007/s10552-014-0376-4